26 Principal Investigator jobs in Canada

Kelowna, BC (On-site, Full-time/Part-time Permanent)

Introduction

We are currently seeking a Principal Investigator for our client, a growing, mission-driven organization in the drug development space. The role of a Principal Investigator is to lead early- and late-phase clinical trials in accordance with ICH-GCP and Health Canada regulations.

This is an exciting opportunity for a seeking a dedicated and experienced physician who is passionate about advancing medicine through research, enjoys patient interaction, and is ready to take on a visible leadership role within a high-performing clinical operations team.

Responsibilities

• Serve as the medical lead for assigned clinical trials, providing oversight from startup through closeout
• Ensure full compliance with study protocols, GCP, and applicable regulatory requirements
• Conduct informed consent discussions and perform study-related medical assessments
• Collaborate with site staff including study coordinators, regulatory specialists, and recruitment teams
• Review and assess adverse events, ensuring timely reporting and medical accuracy
• Participate in sponsor meetings, site selection visits, monitoring visits, and audits as needed
• Support the scientific and operational growth of the site by helping to assess new trial feasibility

Requirements

• Medical Doctor (MD) or Doctor of Osteopathic Medicine (DO) licensed in British Columbia with a minimum of 5 years of practice
• Experience as a Principal Investigator or Sub-Investigator in clinical trials (preferred)
• Familiarity with ICH-GCP guidelines, clinical trial protocols, and Health Canada regulations
• Medical specialization or clinical experience in Neurology, Neurodegenerative disorders, or CNS-related fields (preferred)
• Strong communication and organizational skills
• Ability to work on-site in Kelowna
• Interest in contributing to the development of new therapies across a range of therapeutic areas (e.g., vaccines, CNS, metabolic disease, dermatology)

What We Offer

Why apply through Brunel? Finding the next step in your career can be a full-time job in itself. We manage the process for you: from submitting your resume to coordinating interviews to extending offers and assisting with onboarding. We will get you going while you get on with the job.

About Us

Brunel has a reputation for working with some of the best in the business. That is what we continually strive for. Over 45 years, we have created a global network of interesting clients and talented individuals working together through a vast array of services.

Job Description

Salary: $100,000 - $70,000

About the Role:

At Sonic Incytes, theproductdevelopment team plays an integral role in shaping our product and satisfying our customers needs.
This role focuses on developing and refining signal processing and image reconstruction algorithms tailored for accurate and reliable quantitative ultrasound measurements.

Reporting to the Director, Product Development, theLead Research and Development Engineerwill lead, and collaborate with, cross-functional agile teams to drive the design, development, and deployment of innovative features and advanced solutions that address complex user and product challenges. This role is instrumental in shaping the technical direction of Sonic Incytes' products through hands-on development, system architecture, strategic planning, testing, documentation, and launch.

The Lead Research & Development Engineer drives end-to-end problem solving across algorithm development, hardware, firmware, and software systems. This role is focused on translating complex technical challenges into practical solutions through hands-on experimentation, cross-disciplinary collaboration, and iterative design. The engineer leads the investigation, prototyping, and refinement of new technologies while promoting rigorous engineering standards, continuous integration, and automated testing to ensure scalable, high-performance solutions.

This role reports to the Director of Product Development and is a hybrid position in Vancouver, BC.

Key Responsibilities

• Lead the development and optimization of signal processing, and quantitative imaging algorithms.

• Drive system-level integration across hardware, firmware, and software to enable accurate and robust quantitative ultrasound measurements.

• Design and oversee experimental validation studies using phantoms and in vivo data to assess performance and reliability.

• Collaborate with clinical, product, and QA/RA teams to translate research outcomes into deployable features and meet regulatory requirements.

• Support root cause analysis and iterative refinement for imaging quality, real-time performance, and system stability.

• Stay current with academic and industry advances in ultrasound physics, medical imaging, and signal processing.
  
  

Qualifications and Experience

• Masters or PhD in Biomedical Engineering, Electrical Engineering, Computer Science, or related field with a focus on medical imaging or signal processing.

• 7+ years of R&D experience in Physics, Electronics and/or Ultrasound.

• Proficiency in C++ and/or Python; experience with MATLAB is a plus.

• Hands-on experience with embedded systems and real-time firmware.

• Strong knowledge of ultrasound physics, transducer technology, and system calibration techniques.

• Proven ability to lead cross-functional engineering projects from concept through to deployment.

• Familiarity with ISO 13485, IEC 62304, or other medical device development standards is an asset.
  

About Sonic Incytes

Sonic Incytes is committed to enhancing patient care through innovative diagnostic solutions. The company's flagship product, VELACUR, equips physicians with an advanced liver imaging tool to combat the growing epidemic of fatty liver disease. VELACUR is an AI guided 3D S-WAVE ultrasound elastography device that measures liver stiffness and attenuation, the two key indicators of fatty liver disease.

Compensation:

• Competitive Salary: Between 100,000 and 170,000 per annum, commensurate with experience.
• Comprehensive Health Benefits: We provide medical, dental, vision, life, and disability insurance starting from day one.
• Paid Vacation: Receive 3 weeks of paid vacation annually.
• Employee Stock-Option Plan: Participate in our rewarding employee stock-option award plan.

Why Should you Join Sonic Incytes?

• Rare opportunity to join a company actively making a difference for patients who are afflicted with chronic liver disease, an emerging global health crisis.
• Join an energetic and diverse team who are endlessly curious and wildly passionate about what we do.
• A chance to work within a fast-paced, growing start-up company with lots of opportunities for personal and professional development.

We are proud to be an equal opportunity employer, committed to creating a diverse and inclusive workplace for all. We believe that diverse perspectives drive innovation and success. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.

Are you wanting to have a positive impact and up for a new challenge? If yes, we want to hear from you!

Due to the high volume of applicants, only those selected for an interview will be contacted.

For more information about the company, please visit

Job Description

Company Description

PSI is a leading Contract Research Organization with more 30 years in the industry, offering a perfect balance between stability and innovation to both clients and employees.  We focus on delivering quality and on-time services across a variety of therapeutic indications.

• Coordinates investigator/ site feasibility and identification process, as well as study startup.
• Monitors project timelines and patient enrollment, implements respective corrective and preventive measures.
• Reviews monitoring visit reports for all visit types and ensures reporting compliance of the Monitors in the region.
• Manages Monitors in the query resolution process, including Central Monitoring observations.
• Coordinates safety information flow and protocol/process deviation reporting.
• Performs clinical supplies management with vendors on a country and regional level.
• Ensures study-specific and corporate tracking systems are updated in a timely manner.
• Acts as the main communication line between Monitor, Site Management Associate, Regional Project Lead, and/ Project Manager.
• Coordinates planning of supervised monitoring visits and conducts the visits. 
• Manages the project team in site contracting and payments.
• Leads project team calls on a country level as well as provides status updates and reports to Regional Lead/ Project Manager.
• Ensures ongoing evaluation of data integrity and compliance at a country/regional level.
• Conducts site audit preparation visits, may participate in site audits, and coordinates resolution of site audit findings on a country/regional level.
• Oversees project team in CAPA development and implementation.
• Coordinates project team in process deviations review, management and reporting.
• Conducts initial training and authorization monitoring visits for Monitors and acts as a mentor for newly promoted Lead CRAs.
• Provides project-specific training and prepares training materials for the project team under supervision of a Project Manager and Regional Project Lead.
• Delivers trainings and presentations at Investigator Meetings.
• Prepares, conducts and reports site selection, initiation, routine monitoring and closeout visits.
• Ensures that subject recruitment targets and project timelines are properly defined, communicated, recorded, and met at site level.
• Ensures accurate and timely information flow with trial sites on Adverse Events and protocol/process deviations.
• Supervises source data verification and follows up on data queries at site level in the country/region; reviews and manages study risks on a site level.
• Ensures proper handling, use, accountability, reconciliation, and return of all Investigational Product(s) and clinical study supplies on a country/region level.
• Reviews essential study documents and supervises reconciliation of study Investigator Site File (ISF) / TMF at site level and country/region level.
• Ensures data integrity and compliance at a site level.
• Supervises Site Management Associates in the flow of documents and laboratory supplies between the site and the Central/ Regional Lab/ Central Reviewer.
• Conducts project-specific training of site Investigators.
• Supports preparation of draft regulatory and ethics committee submission packages.

• Relevant educational background, such as MD, MPharm, RN or College/University degree in Life Sciences or an equivalent combination of education, training and experience.
• Minimum of 5 years’ site monitoring experience with participation in global clinical projects as a Lead Monitor. 
• Must have prior experience monitoring or managing sites and CRAs in the United States with knowledge of US regulatory guidelines and practices. 
• Experience with all types of monitoring visits in Phases I-III. 
• Strong experience in Oncology preferred.
• Experience in CAR-T Therapy or other types of Cell Therapy, Gene Therapy, Radiation Therapy or Radiopharmaceuticals, or Nuclear Medicine is preferred. 
• Strong experience in GI (Chron's, Ulcerative Colitis, IBS) preferred. 
• Full working proficiency in English.
• Proficiency in MS Office applications.
• Ability to plan, multitask and work in a dynamic team environment.
• Excellent Communication, collaboration, and problem-solving skills.
• Ability to travel up to 65% (depending on project needs).
• Valid driver’s license (if applicable).

All your information will be kept confidential according to EEO guidelines.

For this position, PSI is not hiring individuals who require work visa for employment or continued employment now or anytime in the future.

We are looking for an advanced physicist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model.

In this role you will need to hold an expert understanding of physics- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to:
Astrophysics, Biophysics, Electrical Engineering, Nuclear Engineering, Chemical Engineering, Mathematics.

Benefits:

• This is a full-time or part-time REMOTE position
• You’ll be able to choose which projects you want to work on
• You can work on your own schedule
• Projects are paid hourly starting at $40+ per hour, with bonuses on high-quality and high-volume work

Responsibilities:

• Give AI chatbots diverse and complex physics problems and evaluate their outputs
• Evaluate the quality produced by AI models for correctness and performance

Qualifications:

• Fluency in English (native or bilingual level)
• Detail-oriented
• Proficient in mathematics, inductive/deductive reasoning, physical/temporal/ spatial reasoning
• A current, in progress, or completed Masters and/or PhD is preferred but not required

Note:
Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. This job is only available to those in the US, UK, Canada, Australia, or New Zealand. Those located outside of these countries will not see work or assessments available on our site at this time.

We are looking for an advanced physicist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model.

In this role you will need to hold an expert understanding of physics- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to:
Astrophysics, Biophysics, Electrical Engineering, Nuclear Engineering, Chemical Engineering, Mathematics.

Benefits:

• This is a full-time or part-time REMOTE position
• You’ll be able to choose which projects you want to work on
• You can work on your own schedule
• Projects are paid hourly starting at $40+ per hour, with bonuses on high-quality and high-volume work

Responsibilities:

• Give AI chatbots diverse and complex physics problems and evaluate their outputs
• Evaluate the quality produced by AI models for correctness and performance

Qualifications:

• Fluency in English (native or bilingual level)
• Detail-oriented
• Proficient in mathematics, inductive/deductive reasoning, physical/temporal/ spatial reasoning
• A current, in progress, or completed Masters and/or PhD is preferred but not required

Note:
Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. This job is only available to those in the US, UK, Canada, Australia, or New Zealand. Those located outside of these countries will not see work or assessments available on our site at this time.

We are looking for an advanced physicist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model.

In this role you will need to hold an expert understanding of physics- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to:
Astrophysics, Biophysics, Electrical Engineering, Nuclear Engineering, Chemical Engineering, Mathematics.

Benefits:

• This is a full-time or part-time REMOTE position
• You’ll be able to choose which projects you want to work on
• You can work on your own schedule
• Projects are paid hourly starting at $40+ per hour, with bonuses on high-quality and high-volume work

Responsibilities:

• Give AI chatbots diverse and complex physics problems and evaluate their outputs
• Evaluate the quality produced by AI models for correctness and performance

Qualifications:

• Fluency in English (native or bilingual level)
• Detail-oriented
• Proficient in mathematics, inductive/deductive reasoning, physical/temporal/ spatial reasoning
• A current, in progress, or completed Masters and/or PhD is preferred but not required

Note:
Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. This job is only available to those in the US, UK, Canada, Australia, or New Zealand. Those located outside of these countries will not see work or assessments available on our site at this time.

Job Description We are looking for an advanced physicist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of physics- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Astrophysics, Biophysics, Electrical Engineering, Nuclear Engineering, Chemical Engineering, Mathematics. Benefits: This is a full-time or part-time REMOTE position You’ll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex physics problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: Fluency in English (native or bilingual level) Detail-oriented Proficient in mathematics, inductive/deductive reasoning, physical/temporal/ spatial reasoning A current, in progress, or completed Masters and/or PhD is preferred but not required Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. This job is only available to those in the US, UK, Canada, Australia, or New Zealand. Those located outside of these countries will not see work or assessments available on our site at this time.